Synthesis and antimalarial evaluation of amide and urea derivatives based on the thiaplakortone A natural product scaffold-Reference-Cited by-同舟云学术

Synthesis and antimalarial evaluation of amide and urea derivatives based on the thiaplakortone A natural product scaffold

Published:2015 Issue:5 Volume:13 Page:1558-1570
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Schwartz Brett D.¹²³⁴,Skinner-Adams Tina S.¹²³⁴,Andrews Katherine T.¹²³⁴,Coster Mark J.¹²³⁴,Edstein Michael D.⁵³⁴,MacKenzie Donna⁵³⁴,Charman Susan A.⁶⁷⁸⁴,Koltun Maria⁶⁷⁸⁴,Blundell Scott⁶⁷⁸⁴,Campbell Anna⁶⁷⁸⁴,Pouwer Rebecca H.¹²³⁴,Quinn Ronald J.¹²³⁴,Beattie Karren D.¹²³⁴,Healy Peter C.¹²³⁴,Davis Rohan A.¹²³⁴

Affiliation:

1. Eskitis Institute for Drug Discovery

2. Griffith University

3. Brisbane

4. Australia

5. Australian Army Malaria Institute

6. Centre for Drug Candidate Optimisation

7. Monash University

8. Parkville

Abstract

A series of amide and urea analogues based on the thiaplakortone A natural product scaffold were synthesised and screened forin vitroantimalarial activity.

Funder

National Health and Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB01849D

Reference29 articles.

1. Global malaria mortality between 1980 and 2010: a systematic analysis

2. First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children

3. Randomized, controlled trial of the long term safety, immunogenicity and efficacy of RTS,S/AS02D malaria vaccine in infants living in a malaria-endemic region