Antimalarial activity of novel 4-cyano-3-methylisoquinoline inhibitors against Plasmodium falciparum: design, synthesis and biological evaluation-Reference-Cited by-同舟云学术

Antimalarial activity of novel 4-cyano-3-methylisoquinoline inhibitors against Plasmodium falciparum: design, synthesis and biological evaluation

Published:2016 Issue:20 Volume:14 Page:4617-4639
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Buskes Melissa J.¹²³⁴⁵,Harvey Katherine L.⁶⁷⁴⁵⁸,Richards Benjamin J.¹²³⁴⁵,Kalhor Robabeh¹²³⁴⁵,Christoff Rebecca M.¹²³⁴⁵,Gardhi Chamodi K.¹²³⁴⁵,Littler Dene R.⁹⁴⁵,Cope Elliott D.⁶⁷⁴⁵,Prinz Boris⁶⁷⁴⁵,Weiss Greta E.⁶⁷⁴⁵,O'Brien Nathan J.¹²³⁴⁵,Crabb Brendan S.⁶⁷⁴⁵⁸,Deady Leslie W.¹²³⁴⁵,Gilson Paul R.⁶⁷⁴⁵⁹,Abbott Belinda M.¹²³⁴⁵

Affiliation:

1. Department of Chemistry and Physics

2. La Trobe Institute for Molecular Science

3. La Trobe University

4. Melbourne

5. Australia

6. Centre for Biomedical Research

7. Burnet Institute

8. Department of Microbiology and Immunology

9. Monash University

Abstract

A series of 4-cyano-3-methylisoquinolines have been shown to inhibit parasite cytokinesis and erythrocyte invasion.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C5OB02517F

Reference57 articles.

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5. Cell division in apicomplexan parasites

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