Synthesis, radiolabeling with fluorine-18 and preliminary in vivo evaluation of a heparan sulphate mimetic as potent angiogenesis and heparanase inhibitor for cancer applications-Reference-Cited by-同舟云学术

Synthesis, radiolabeling with fluorine-18 and preliminary in vivo evaluation of a heparan sulphate mimetic as potent angiogenesis and heparanase inhibitor for cancer applications

Published:2016 Issue:6 Volume:14 Page:1915-1920
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Kuhnast B.¹²³⁴⁵,El Hadri A.⁶⁷⁸⁵⁹,Boisgard R.¹²³⁴⁵,Hinnen F.¹²³⁴⁵,Richard S.⁶⁷⁸⁵,Caravano A.⁶⁷⁸⁵,Nancy-Portebois V.⁶⁷⁸⁵,Petitou M.⁶⁷⁸⁵,Tavitian B.¹⁰¹¹¹²¹³¹⁴,Dollé F.¹²³⁴⁵

Affiliation:

1. CEA

2. Institut d'imagerie biomédicale

3. Service Hospitalier Frédéric Joliot

4. 91400 Orsay

5. France

6. Endotis Pharma

7. Biocitech Park

8. 93230 Romainville

9. CarboMimetics

10. Laboratoire PARCC UMR 970 Inserm/Université Paris Descartes

11. Sorbonne Paris Cité

12. Assistance Publique – Hôpitaux de Paris

13. Hôpital Européen Georges Pompidou

14. 75015 Paris

Abstract

A rationally designed, fully synthetic, octasaccharide-based, HS mimetic has been synthesized, in vitro characterized, labeled with fluorine-18, and in vivo imaged with PET in rats.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C5OB02513C

Reference25 articles.

1. Roles of heparan-sulphate glycosaminoglycans in cancer

2. Involvement of stromal proteoglycans in tumour progression

3. Tumorigenesis and the angiogenic switch

4. Angiogenesis in cancer and other diseases

5. Therapeutic options to target angiogenesis in human malignancies

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