Oxa-376 and Oxa-530 variants of β-lactamase: computational study uncovers potential therapeutic targets of <i>Acinetobacter baumannii</i>-Reference-Cited by-同舟云学术

Oxa-376 and Oxa-530 variants of β-lactamase: computational study uncovers potential therapeutic targets of Acinetobacter baumannii

Published:2022 Issue:37 Volume:12 Page:24319-24338
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Halder Sajal Kumar¹²^ORCID,Mim Maria Mulla³,Alif Md. Meharab Hassan¹^ORCID,Shathi Jannatul Fardous¹,Alam Nuhu⁴,Shil Aparna⁴^ORCID,Himel Mahbubul Kabir⁴

Affiliation:

1. Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh

2. Research Assistant at Padma Bioresearch, Dhaka, Bangladesh

3. Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh

4. Department of Botany, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh

Abstract

Determining novel therapeutic targets of Acinetobacter baumannii. Deleterious variants, causing antibiotic resistance, were identified by molecular docking and molecular dynamics simulation suggesting new therapeutic targets Oxa-376 and Oxa-530.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA02939A

Reference60 articles.

1. Antimicrobial Resistance:Acinetobacter baumannii:Epidemiology, Antimicrobial Resistance, and Treatment Options

2. Acinetobacter baumannii : Emergence of a Successful Pathogen

3. Global Challenge of Multidrug-Resistant Acinetobacter baumannii

4. Acinetobacter spp. as nosocomial pathogens: Epidemiology and resistance features

5. An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii

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