Synthesis and antifungal screening of tetramethyl hexahydro-1H-xanthene-1,8(2H)-dione derivatives as potential inhibitors of morphogenesis and biofilm formation in Candida albicans-Reference-Cited by-同舟云学术

Synthesis and antifungal screening of tetramethyl hexahydro-1H-xanthene-1,8(2H)-dione derivatives as potential inhibitors of morphogenesis and biofilm formation in Candida albicans

Published:2022 Issue:5 Volume:46 Page:2128-2139
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Kasabe Umesh I.¹^ORCID,Kale Kishor B.²,Rode Nitin R.²,Shelar Amruta V.³,Patil Rajendra H.⁴,Mhaske Pravin C.⁵^ORCID,Chaskar Manohar G.¹⁶^ORCID

Affiliation:

1. Department of Chemistry, Baburaoji Gholap College (Affiliated to Savitribai Phule Pune University, Pune), Sangvi, Pune-411027, India

2. Department of Chemistry, Nowrosjee Wadia College (Affiliated to Savitribai Phule Pune University, Pune), Pune-411001, India

3. Department of Technology, Savitribai Phule Pune University, Pune-411007, India

4. Department of Biotechnology, Savitribai Phule Pune University, Pune-411007, India

5. Department of Chemistry, Sir Parashurambhau College (Affiliated to Savitribai Phule Pune University, Pune), Pune-411030, India

6. Dean, Science and Technology, Savitribai Phule Pune University, Pune-411007, India

Abstract

A series of hexahydro-1H-xanthene-1,8(2H)-dione derivatives were synthesized. All the derivatives were screened for their anti-virulence properties against Candida albicans. In silico studies were performed to corroborate the experimentally observed facts.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D1NJ04168A

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