Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design-Reference-Cited by-同舟云学术

Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design

Published:2019 Issue:5 Volume:10 Page:1522-1530
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Li Xiang¹²³⁴⁵,Tolbert W. David⁵⁶⁷⁸⁹,Hu Hong-Gang¹²³⁴^ORCID,Gohain Neelakshi⁵⁶⁷⁸⁹,Zou Yan¹²³⁴^ORCID,Niu Fan⁵⁶⁷⁸⁹,He Wang-Xiao⁵⁶⁷⁸⁹,Yuan Weirong⁵⁶⁷⁸⁹,Su Jia-Can¹⁰²³⁴^ORCID,Pazgier Marzena⁵⁶⁷⁸⁹,Lu Wuyuan⁵⁶⁷⁸⁹^ORCID

Affiliation:

1. School of Pharmacy

2. Second Military Medical University

3. Shanghai 200433

4. China

5. Institute of Human Virology and Department of Biochemistry and Molecular Biology

6. University of Maryland

7. School of Medicine

8. Baltimore

9. USA

10. Changhai Hospital

Abstract

A novel peptide stapling strategy based on the dithiocarbamate chemistry linking the side chains of residues Lys(i) and Cys(i + 4) of unprotected peptides is developed.

Funder

China Scholarship Council

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C8SC03275K

Reference63 articles.

1. Inhibition of α-helix-mediated protein–protein interactions using designed molecules

2. Principles of Protein−Protein Interactions: What are the Preferred Ways For Proteins To Interact?