Phosphorus oxychloride as an efficient coupling reagent for the synthesis of esters, amides and peptides under mild conditions-Reference-Cited by-同舟云学术

Phosphorus oxychloride as an efficient coupling reagent for the synthesis of esters, amides and peptides under mild conditions

Published:2013 Issue:37 Volume:3 Page:16247-16250
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Chen Hu¹²³⁴⁵,Xu Xunfu¹²³⁴⁵,Liu Liu Leo¹²³⁴⁵,Tang Guo¹²³⁴⁵,Zhao Yufen¹²³⁴⁵

Affiliation:

1. Department of Chemistry

2. College of Chemistry and Chemical Engineering

3. and the Key Laboratory for Chemical Biology of Fujian Province

4. Xiamen University

5. Xiamen

Abstract

A mild method is described for the conversion of carboxylic acids into esters, amides, as well as peptides without racemization through carboxyl activation by the reagent combination of POCl₃ and DMAP.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2013/RA/C3RA42887G

Reference37 articles.

1. J. Otera and J.Nishikido , Esterification: Methods, Reactions, and Applications , Wiley-VCH , Weinheim , 2nd ed., 2010

2. Rethinking amide bond synthesis

3. Simple Method for the Esterification of Carboxylic Acids

4. Direct room temperature esterification of carboxylic acids

5. A Rapid Esterification by Means of Mixed Anhydride and Its Application to Large-ring Lactonization

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