Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green-Reference-Cited by-同舟云学术

Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green

Published:2023 Issue:13 Volume:14 Page:3462-3469
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Freiberg Kaitlyn M.¹^ORCID,Kavthe Rahul D.¹,Thomas Rohan M.¹,Fialho David M.¹,Dee Paris¹,Scurria Matthew¹,Lipshutz Bruce H.¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, 93106, USA

Abstract

Technology for generating especially important amide and peptide bonds from carboxylic acids and amines that avoids traditional coupling reagents is described.

Funder

Bill and Melinda Gates Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC00198A

Reference73 articles.

1. Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

2. Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals

3. Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution

4. Simple Synthesis of Amides via Their Acid Chlorides in Aqueous TPGS-750-M

5. Hydrophobic Pockets of HPMC Enable Extremely Short Reaction Times in Water

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Rapid Aminations of Functionalized Aryl Fluorosulfates in Water;Angewandte Chemie;2024-09-06

2. Rapid Aminations of Functionalized Aryl Fluorosulfates in Water;Angewandte Chemie International Edition;2024-09-06

3. Amidation of β‐Keto Sulfonyl Fluorides via C−C Bond Cleavage;European Journal of Organic Chemistry;2024-07-04

4. Dehydration in Water: A Reagentless and Straightforward Synthesis of Tetrahydroquinazolines under Microwave Irradiation or by Stirring at Room Temperature, and Their Subsequent Conversion into Quinazolines in a Micellar Medium;Synthesis;2024-06-19

5. Reducing the cost of making drugs for low/limited-income countries by going green;Trends in Chemistry;2024-04