Selectivity hot-spots of sirtuin catalytic cores-Reference-Cited by-同舟云学术

Selectivity hot-spots of sirtuin catalytic cores

Published:2015 Issue:8 Volume:11 Page:2263-2272
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Parenti Marco Daniele¹²³⁴,Bruzzone Santina⁵⁶⁷⁸⁹,Nencioni Alessio¹⁰⁸⁹⁴,Del Rio Alberto¹²³⁴¹¹^ORCID

Affiliation:

1. Department of Experimental, Diagnostic and Specialty Medicine (DIMES)

2. University of Bologna

3. 40126 Bologna

4. Italy

5. Department of Experimental Medicine

6. Section of Biochemistry

7. and CEBR

8. University of Genoa

9. 16132 Genoa

10. Department of Internal Medicine

11. Institute of Organic Synthesis and Photoreactivity (ISOF)

Abstract

We report a comprehensive study aimed to classify and identify the selectivity hot-spots for targeting the catalytic cores of human sirtuins using small molecule modulators.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MB/C5MB00205B

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1. The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.

2. SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive

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5. Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern

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