Synthesis of disulfide-bridging trehalose polymers for antibody and Fab conjugation using a bis-sulfone ATRP initiator-Reference-Cited by-同舟云学术

Synthesis of disulfide-bridging trehalose polymers for antibody and Fab conjugation using a bis-sulfone ATRP initiator

Published:2021 Issue:9 Volume:12 Page:1217-1223
ISSN:1759-9954
Container-title:Polymer Chemistry
language:en
Short-container-title:Polym. Chem.

Author:

Forsythe Neil L.¹²³⁴,Maynard Heather D.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry and California NanoSystems Institute

2. 607 Charles E. Young Drive East

3. University of California

4. Los Angeles

Abstract

Herein is reported a bis-sulfone ATRP initiator capable of inserting into the disulfide bonds of antibodies. Further, we present trehalose methacrylate polymers made with this initiator that effectively stabilize antibodies to heat as conjugates.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/PY/D0PY01579B

Reference44 articles.

1. Development of therapeutic antibodies for the treatment of diseases

2. The therapeutic monoclonal antibody market

3. Monoclonal Antibodies as Innovative Therapeutics

4. Antibody fragments

5. The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor.

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