Enhancement of antiproliferative activity by phototautomerization of anthrylphenols-Reference-Cited by-同舟云学术

Enhancement of antiproliferative activity by phototautomerization of anthrylphenols

Published:2015 Issue:6 Volume:14 Page:1082-1092
ISSN:1474-905X
Container-title:Photochemical & Photobiological Sciences
language:en
Short-container-title:Photochem. Photobiol. Sci.

Author:

Kralj Marijeta¹²³⁴,Uzelac Lidija¹²³⁴,Wang Yu-Hsuan⁵⁶⁷⁸⁹,Wan Peter⁵⁶⁷⁸⁹,Tireli Martina¹⁰²³⁴,Mlinarić-Majerski Kata¹⁰²³⁴,Piantanida Ivo¹⁰²³⁴,Basarić Nikola¹⁰²³⁴

Affiliation:

1. Department of Molecular Medicine

2. Ruđer Bošković Institute

3. 10 000 Zagreb

4. Croatia

5. Department of Chemistry

6. Box 3065

7. University of Victoria

8. Victoria

9. Canada

10. Department of Organic Chemistry and Biochemistry

Abstract

9-(2-Hydroxyphenyl)anthracene (1) moderately inhibited the proliferation of human cancer cells, but irradiation considerably enhanced the effect due to the formation of quinone methide. The effect is not only due to the damage of DNA, but also due to the impact on the cellular proteins.

Funder

Hrvatska Zaklada za Znanost

Publisher

Springer Science and Business Media LLC

Subject

Physical and Theoretical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/PP/C5PP00099H

Reference56 articles.

1. Quinone Methides, ed. S. E. Rokita, Wiley, Hoboken, USA, 2009

2. o-Quinone methides: intermediates underdeveloped and underutilized in organic synthesis

3. Applications of ortho-Quinone Methide Intermediates in Catalysis and Asymmetric Synthesis