A Pd-labile fluoroquinolone prodrug efficiently prevents biofilm formation on coated surfaces-Reference-Cited by-同舟云学术

A Pd-labile fluoroquinolone prodrug efficiently prevents biofilm formation on coated surfaces

Published:2024 Issue:10 Volume:22 Page:1998-2002
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Braun Josef¹,Ortega-Liebana M. Carmen²³⁴⁵⁶^ORCID,Unciti-Broceta Asier²³^ORCID,Sieber Stephan A.¹^ORCID

Affiliation:

1. Technical University of Munich, TUM School of Natural Sciences, Department of Bioscience, Center for Functional Protein Assemblies (CPA), Ernst-Otto-Fischer Strasse 8, 85748 Garching bei München, Germany

2. Edinburgh Cancer Research, Institute of Genetics and Cancer, University of Edinburgh, EH4 2XR Edinburgh, UK

3. CRUK Scotland Centre, UK

4. Department of Medicinal & Organic Chemistry and Unit of Excellence in Chemistry Applied to Biomedicine and the Environment, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain

5. GENYO, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, 18016 Granada, Spain

6. Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain

Abstract

We introduce hydrogel-coated surfaces loaded with tailored Pd-nanosheets which catalyze the release of antibiotics from inactive prodrugs to prevent the formation of Staphylococcus aureus biofilms.

Funder

Engineering and Physical Sciences Research Council

Horizon 2020 Framework Programme

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00014E

Reference28 articles.

1. Bacterial Extracellular Polysaccharides in Biofilm Formation and Function

2. Implant infections: adhesion, biofilm formation and immune evasion

3. Antibiotic treatment of biofilm infections

4. Treatment of staphylococcal implant infection with rifampicin-ciprofloxacin in stable implants

5. Fluoroquinolone antibiotics and adverse events

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