Structure-guided semi-rational design of an imine reductase for enantio-complementary synthesis of pyrrolidinamine-Reference-Cited by-同舟云学术

Structure-guided semi-rational design of an imine reductase for enantio-complementary synthesis of pyrrolidinamine

Published:2023 Issue:16 Volume:14 Page:4265-4272
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zhang Jun¹²^ORCID,Ma Yaqing¹³,Zhu Fangfang¹⁴,Bao Jinping¹,Wu Qiaqing¹⁵^ORCID,Gao Shu-Shan¹⁵,Cui Chengsen¹⁵^ORCID

Affiliation:

1. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China

2. School of Life Science, Hebei University, Baoding 071002, China

3. CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

4. College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China

5. National Technology Innovation Center of Synthetic Biology, Tianjin 300308, China

Abstract

In this study, engineered imine reductases (IREDs) of IRED M5, originally fromActinoalloteichus hymeniacidonis, were obtained through structure-guided semi-rational design.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D2SC07014F

Reference47 articles.

1. Reductive Amination in the Synthesis of Pharmaceuticals