PAC-FragmentDEL – photoactivated covalent capture of DNA-encoded fragments for hit discovery-Reference-Cited by-同舟云学术

PAC-FragmentDEL – photoactivated covalent capture of DNA-encoded fragments for hit discovery

Published:2022 Issue:11 Volume:13 Page:1341-1349
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Ma Huiyong¹^ORCID,Murray James B.²,Luo Huadong¹,Cheng Xuemin¹,Chen Qiuxia¹^ORCID,Song Chao¹,Duan Cong¹,Tan Ping¹,Zhang Lifang¹,Liu Jian¹,Morgan Barry A.¹,Li Jin¹,Wan Jinqiao¹^ORCID,Baker Lisa M.²^ORCID,Finnie William²,Guetzoyan Lucie²,Harris Richard²^ORCID,Hendrickson Nicole²,Matassova Natalia²,Simmonite Heather²,Smith Julia²,Hubbard Roderick E.²^ORCID,Liu Guansai¹^ORCID

Affiliation:

1. HitGen Inc., Building 6, No. 8 Huigu First East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu 610000, Sichuan, P. R. China

2. Vernalis (R&D) Ltd, Granta Park, Abington, Cambridge, CB21 6GB, UK

Abstract

Fragments bind weakly to specific sites on proteins. A library where a photoactivatable group is linked to DNA encoded fragments covalently links the protein to binding fragments whose identity is determined by PCR and sequencing.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D2MD00197G

Reference36 articles.

1. Twenty years on: the impact of fragments on drug discovery

2. Recent progress in fragment-based lead discovery

3. Fragment-to-Lead Medicinal Chemistry Publications in 2020

4. D. A.Erlanson , Practical fragments blog – fragments in the clinic , 2021

5. Molecular complexity and fragment-based drug discovery: ten years on

Cited by 16 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Highly pure DNA-encoded chemical libraries by dual-linker solid-phase synthesis;Science;2024-06-14

2. Building Block-Centric Approach to DNA-Encoded Library Design;Journal of Chemical Information and Modeling;2024-06-11

3. Using DNA-encoded libraries of fragments for hit discovery of challenging therapeutic targets;Expert Opinion on Drug Discovery;2024-05-16

4. Photoaffinity labelling with small molecules;Nature Reviews Methods Primers;2024-05-02

5. DNA-Encoded Library Technology─A Catalyst for Covalent Ligand Discovery;ACS Chemical Biology;2024-03-25