A desferrioxamine B squaramide ester for the incorporation of zirconium-89 into antibodies-Reference-Cited by-同舟云学术

A desferrioxamine B squaramide ester for the incorporation of zirconium-89 into antibodies

Published:2016 Issue:80 Volume:52 Page:11889-11892
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Rudd Stacey E.¹²³⁴,Roselt Peter⁵⁶⁷⁴,Cullinane Carleen⁵⁶⁷⁴⁸,Hicks Rodney J.⁸⁹¹⁰⁴¹¹,Donnelly Paul S.¹²³⁴

Affiliation:

1. School of Chemistry and Bio21 Molecular Science and Biotechnology Institute

2. University of Melbourne

3. Melbourne

4. Australia

5. Research Division

6. Peter MacCallum Cancer Centre

7. Melbourne 3000

8. The Sir Peter MacCallum Department of Oncology

9. The University of Melbourne

10. Parkville

11. Centre for Cancer Imaging

Abstract

A squaramide ester derivative of desferrioxamine B is used to attach zirconium-89 to the antibody trastuzumab and the new conjugate is used for positron emission tomography imaging in mouse models of breast cancer.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C6CC05961A

Reference20 articles.

1. Antibody therapy of cancer

2. Radioimmunoimaging with Longer-Lived Positron-Emitting Radionuclides: Potentials and Challenges

3. Development and Characterization of Clinical-Grade 89Zr-Trastuzumab for HER2/neu ImmunoPET Imaging

4. 89Zr-DFO-J591 for ImmunoPET of Prostate-Specific Membrane Antigen Expression In Vivo

5. Standardized methods for the production of high specific-activity zirconium-89

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