2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2-Reference-Cited by-同舟云学术

2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2

Published:2018 Issue:25 Volume:54 Page:3130-3133
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Abboud Martine I.¹²³⁴^ORCID,McAllister Tom E.¹²³⁴^ORCID,Leung Ivanhoe K. H.¹²³⁴⁵^ORCID,Chowdhury Rasheduzzaman¹²³⁴^ORCID,Jorgensen Christian⁶⁷⁸⁴^ORCID,Domene Carmen¹²³⁴⁶,Mecinović Jasmin¹²³⁴⁹^ORCID,Lippl Kerstin¹²³⁴,Hancock Rebecca L.¹²³⁴,Hopkinson Richard J.¹²³⁴¹⁰^ORCID,Kawamura Akane¹²³⁴^ORCID,Claridge Timothy D. W.¹²³⁴^ORCID,Schofield Christopher J.¹²³⁴^ORCID

Affiliation:

1. Chemistry Research Laboratory

2. University of Oxford

3. Oxford

4. UK

5. School of Chemical Sciences

6. Department of Chemistry

7. Britannia House

8. Kings College London

9. Institute for Molecules and Materials

10. Leicester Institute of Structural and Chemical Biology and Department of Chemistry

Abstract

The binding of prolyl-hydroxylated HIF-α to PHD2 is hindered by prior 2OG binding; likely, leading to the inhibition of HIF-α degradation under limiting 2OG conditions.

Funder

Biochemical Society

BHF Centre of Research Excellence, Oxford

Biotechnology and Biological Sciences Research Council

John Fell Fund, University of Oxford

Cancer Research UK

Wellcome Trust

Kellogg College, University of Oxford

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC00387D

Reference30 articles.

1. PROLINE HYDROXYLATION AND GENE EXPRESSION

2. Pharmacological targeting of the HIF hydroxylases – A new field in medicine development

3. Targeting Protein-Protein Interactions in the HIF System

4. Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL

5. Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

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