3,3-Dibromo-2-trifluoromethyl acrylic acid ethyl ester: a versatile platform for the stereoselective preparation of functionalized-α-trifluoromethyl α,β-unsaturated lactones and trifluoromethyl pyrazolinones

Author:

Mizuta Satoshi1234,Otaki Hiroki1234,Kitamura Kanami1234,Nishi Kodai56234,Watanabe Ken1234,Makau Juliann Nzembi1234,Hashimoto Ryo784,Usui Toshiya784,Chiba Kenya784

Affiliation:

1. Graduate School of Biomedical Sciences

2. Nagasaki University

3. Nagasaki

4. Japan

5. Department of Radioisotope Medicine

6. Atomic Bomb Disease institute

7. Nishiisahaya Hospital

8. Nagasaki 854-0063

Abstract

Synthetic routes to multi-functionalized-α-trifluoromethyl α,β-unsaturated lactones and trifluoromethyl pyrazolinones.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Reference48 articles.

1. Biomedical Frontiers of Fluorine Chemistry, ACS Symposium Series 639, ed. I. Ojima, J. R. McCarthy and J. T. Welch, American Chemical Society, Washington, DC, 1996

2. Fluorine in Pharmaceuticals: Looking Beyond Intuition

3. Fluorine in medicinal chemistry

4. Fluorine in Medicinal Chemistry and Chemical Biology, ed. I. Ojima, Wiley-Blackwell, United Kingdom, 2009

5. Trifluridine

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