Monitoring isoniazid metabolism <i>in vivo</i> using a near-infrared fluorescent probe-Reference-Cited by-同舟云学术

Monitoring isoniazid metabolism in vivo using a near-infrared fluorescent probe

Published:2022 Issue:23 Volume:14 Page:2284-2292
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Wang Xiaoyan¹,Zhang Juanjuan²,Zhu Jiaqi²,Yuan Zhenwei²^ORCID,Xu Hui³,Ran Jianhua¹

Affiliation:

1. Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing, China

2. Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, Nanjing, China

3. Department of Food Quality and Safety, College of Food Science and Engineering/Collaborative Innovation Center for Modern Grain Circulation and Safety/Key Laboratory of Grains and Oils Quality Control and Processing, Nanjing University of Finance and Economics, Nanjing 210023, China

Abstract

In vivo, isoniazid can be metabolized to produce hydrazine, which is a genotoxic substance. Here, we synthesized a near-infrared fluorescent probe Cy-HZ based on the hemicyanine skeleton to visualize the metabolism of the drug isoniazid in vivo.

Funder

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/AY/D2AY00185C

Reference22 articles.

1. A new “turn-on” fluorescence probe based on hydrazine-triggered tandem reaction

2. A fluorescein-coumarin based ratiometric fluorescent probe for detecting hydrazine and its real applications in cells imaging

3. Detection of hydrazine via a highly selective fluorescent probe: A case study on the reactivity of cyano-substituted C C bond