Monitoring isoniazid metabolism in vivo using a near-infrared fluorescent probe

Author:

Wang Xiaoyan1,Zhang Juanjuan2,Zhu Jiaqi2,Yuan Zhenwei2ORCID,Xu Hui3,Ran Jianhua1

Affiliation:

1. Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing, China

2. Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, Nanjing, China

3. Department of Food Quality and Safety, College of Food Science and Engineering/Collaborative Innovation Center for Modern Grain Circulation and Safety/Key Laboratory of Grains and Oils Quality Control and Processing, Nanjing University of Finance and Economics, Nanjing 210023, China

Abstract

In vivo, isoniazid can be metabolized to produce hydrazine, which is a genotoxic substance. Here, we synthesized a near-infrared fluorescent probe Cy-HZ based on the hemicyanine skeleton to visualize the metabolism of the drug isoniazid in vivo.

Funder

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

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