Facile synthesis of 2-alkynyl oxazoles via a Ce(OTf)3-catalyzed cascade reaction of alkynyl carboxylic acids with tert-butyl isocyanide-Reference-Cited by-同舟云学术

Facile synthesis of 2-alkynyl oxazoles via a Ce(OTf)3-catalyzed cascade reaction of alkynyl carboxylic acids with tert-butyl isocyanide

Published:2020 Issue:4 Volume:18 Page:655-659
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Cao Ming¹²³⁴⁵,Teng Qing-Hu⁶⁷⁸⁹,Xi Zhi-Wei¹²³⁴⁵,Liu Li-Qiu¹²³⁴⁵,Gu Ren-Yong¹²³⁴⁵,Wang Ying-Chun¹²³⁴⁵^ORCID

Affiliation:

1. National Demonstration Center for Experimental Chemistry Education

2. Hunan Engineering Laboratory for Analyse and Drugs Development of Ethnomedicine in Wuling Mountains

3. Jishou University

4. Jishou 416000

5. P. R. China

6. School of Chemistry and Chemical Engineering

7. Beijing Institute of Technology

8. Beijing 100081

9. People's Republic of China

Abstract

We developed an efficient and novel protocol to synthesize 2-alkynyloxazoles from tert-butyl isocyanide and alkynyl carboxylic acids, and these diversely functionalized oxazoles showed a certain degree of biological activity.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/C9OB02337B

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