Design, synthesis, biological assessment and in silico ADME prediction of new 2-(4-(methylsulfonyl) phenyl) benzimidazoles as selective cyclooxygenase-2 inhibitors-Reference-Cited by-同舟云学术

Design, synthesis, biological assessment and in silico ADME prediction of new 2-(4-(methylsulfonyl) phenyl) benzimidazoles as selective cyclooxygenase-2 inhibitors

Published:2021 Issue:44 Volume:11 Page:27659-27673
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Badawy Mohamed A. S.¹^ORCID,Abdelall Eman K. A.²^ORCID,EL-Nahass EL-Shaymaa³^ORCID,Abdellatif Khaled R. A.²⁴^ORCID,Abdel-Rahman Hamdy M.¹⁵^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Nahda University (NUB), Beni-Suef 62513, Egypt

2. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt

3. Department of Pathology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt

4. Pharmaceutical Sciences Department, IbnSina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia

5. Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

Abstract

A novel series of benzimidazole derivatives wherein 4-(methylsulfonyl) phenyl pharmacophore attached via its C-2 position was designed and synthesized.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA04756F

Reference49 articles.

1. Symptomatic treatment of osteoarthritis: paracetamol or NSAIDs?

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