Aryl urea substituted fatty acids: a new class of protonophoric mitochondrial uncoupler that utilises a synthetic anion transporter-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Aryl urea substituted fatty acids: a new class of protonophoric mitochondrial uncoupler that utilises a synthetic anion transporter

Published:2020 Issue:47 Volume:11 Page:12677-12685
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Rawling Tristan¹²³⁴⁵^ORCID,MacDermott-Opeskin Hugo⁶⁷⁸⁹⁵^ORCID,Roseblade Ariane¹²³⁴⁵,Pazderka Curtis¹²³⁴⁵,Clarke Callum¹²³⁴⁵,Bourget Kirsi¹⁰¹¹¹²⁴⁵,Wu Xin¹³¹²⁴⁵,Lewis William¹³¹²⁴⁵,Noble Benjamin⁶⁷⁸⁹⁵,Gale Philip A.¹³¹²⁴⁵^ORCID,O'Mara Megan L.⁶⁷⁸⁹⁵,Cranfield Charles¹⁴²³⁴⁵^ORCID,Murray Michael¹⁰¹¹¹²⁴⁵

Affiliation:

1. School of Mathematical and Physical Sciences

2. Faculty of Science

3. University of Technology Sydney

4. Sydney

5. Australia

6. Research School of Chemistry

7. College of Science

8. The Australian National University

9. Canberra

10. Discipline of Pharmacology

11. School of Medical Sciences

12. University of Sydney

13. School of Chemistry

14. School of Life Sciences

Abstract

A new mitochondrial uncoupler that forms membrane permeable dimers through interactions of remote acidic and anion receptor groups.

Funder

Australian Research Council

National Health and Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC02777D

Reference32 articles.

1. Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential

2. Toward a Class-Independent Quantitative Structure−Activity Relationship Model for Uncouplers of Oxidative Phosphorylation

3. The Development of Structure-Activity Relationships for Mitochondrial Dysfunction: Uncoupling of Oxidative Phosphorylation

4. Protonophoric Activity of Fatty Acid Analogs and Derivatives in the Inner Mitochondrial Membrane: A Further Argument for the Fatty Acid Cycling Model

5. Interaction of free fatty acids with mitochondria: Coupling, uncoupling and permeability transition

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Carbon Chain Length in a Novel Anticancer Aryl‐Urea Fatty Acid Modulates Mitochondrial Targeting, Reactive Oxygen Species Production and Cell Killing;ChemMedChem;2024-08-19

2. Expanding the π‐system of Fatty Acid‐Anion Transporter Conjugates Modulates Their Mechanism of Proton Transport and Mitochondrial Uncoupling Activity;Chemistry – A European Journal;2024-07-31

3. Omega-3 polyunsaturated fatty acid derived lipid mediators: a comprehensive update on their application in anti-cancer drug discovery;Expert Opinion on Drug Discovery;2024-04-09

4. Mechanistic Aspects of Biphenyl Urea-Based Analogues in Triple-Negative Breast Cancer Cell Lines;ACS Pharmacology & Translational Science;2023-12-15

5. Noncoupled Mitochondrial Respiration as Therapeutic Approach for the Treatment of Metabolic Diseases: Focus on Transgenic Animal Models;International Journal of Molecular Sciences;2023-11-18

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号京ICP备18003416号-3