3,5-Diaryl substituted sclerotiorin: a novel scaffold of succinate-ubiquinone oxidoreductase inhibitors-Reference-Cited by-同舟云学术

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3,5-Diaryl substituted sclerotiorin: a novel scaffold of succinate-ubiquinone oxidoreductase inhibitors

Published:2022 Issue:26 Volume:46 Page:12711-12719
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Chen Cheng¹^ORCID,Wang Yu-Xia²,Li Song-Bo²,Wu Qiong-You²^ORCID

Affiliation:

1. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, P. R. China

2. Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China

Abstract

Novel and potent inhibitors targeting succinate-ubiquinone oxidoreductase were discovered from the natural product sclerotiorin for the first time.

Funder

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D2NJ01869A

Reference60 articles.

1. Succinate: quinone oxidoreductases

2. Function and Structure of Complex II of the Respiratory Chain

3. Architecture of Succinate Dehydrogenase and Reactive Oxygen Species Generation

4. Crystal Structure of Mitochondrial Respiratory Membrane Protein Complex II

5. The quinone-binding and catalytic site of complex II

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