Nickel oxide nanoparticles induce developmental neurotoxicity in zebrafish by triggering both apoptosis and ferroptosis

Author:

Wang Zuo1,Bi Yi123,Li Kemin1,Song Zan1,Pan Chuanying2,Zhang Shengxiang1ORCID,Lan Xianyong2,Foulkes Nicholas S.3,Zhao Haiyu1ORCID

Affiliation:

1. School of Life Sciences, Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, Lanzhou University, No. 222 South Tianshui Road, Lanzhou 730000, Gansu Province, China

2. Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, No. 22 Xinong Road, Yangling 712100, Shaanxi Province, China

3. Institute of Biological and Chemical Systems, Biological Information Processing (IBCS-BIP), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz Platz 1, 76344 Eggenstein-Leopoldshafen, Germany

Abstract

NiO-NPs exert toxic effects on zebrafish neurobehavior and neurodevelopment through activation of apoptosis and ferroptosis.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Lanzhou University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Environmental Science,Materials Science (miscellaneous)

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