Unveiling the impact of oxidation-driven endogenous protein interactions on the dynamics of amyloid-β aggregation and toxicity-Reference-Cited by-同舟云学术

Unveiling the impact of oxidation-driven endogenous protein interactions on the dynamics of amyloid-β aggregation and toxicity

Published:2023 Issue:20 Volume:14 Page:5340-5349
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Du Zhi¹²,Nam Eunju¹,Lin Yuxi³,Hong Mannkyu¹⁴,Molnár Tamás⁵,Kondo Ikufumi⁶,Ishimori Koichiro⁶⁷^ORCID,Baik Mu-Hyun¹⁴^ORCID,Lee Young-Ho³⁸⁹¹⁰,Lim Mi Hee¹^ORCID

Affiliation:

1. Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea

2. Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, PR China

3. Research Center for Bioconvergence Analysis, Korea Basic Science Institute (KBSI), Ochang, Chungbuk 28119, Republic of Korea

4. Center for Catalytic Hydrocarbon Functionalizations, Institute for Basic Science (IBS), Daejeon 34141, Republic of Korea

5. Department of Biochemistry, Institute of Biology, Eötvös Loránd University, H-1117 Budapest, Hungary

6. Graduate School of Chemical Sciences and Engineering, Hokkaido University, Kita 13, Nishi 8, Kita-ku, Sapporo 060-8628, Japan

7. Department of Chemistry, Faculty of Science, Hokkaido University, Kita 10, Nishi 8, Kita-ku, Sapporo 060-0810, Japan

8. Bio-Analytical Science, University of Science and Technology (UST), Daejeon 34113, Republic of Korea

9. Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon 34134, Republic of Korea

10. Research Headquarters, Korea Brain Research Institute (KBRI), Daegu 41068, Republic of Korea

Abstract

We illuminate that cytochrome c (Cyt c) directly interacts with amyloid-β (Aβ) and alters Aβ amyloidogenesis in a peroxide-dependent manner, which demonstrates its new role towards the amyloid pathology associated with Alzheimer's disease.

Funder

Institute for Basic Science

National Research Foundation of Korea

National Research Council of Science and Technology

Korea Basic Science Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC00881A

Reference43 articles.

1. The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

2. Bioinorganic Chemistry of Alzheimer’s Disease

3. Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

4. Towards an understanding of amyloid-β oligomers: characterization, toxicity mechanisms, and inhibitors

5. Mechanistic Insight into the Design of Chemical Tools to Control Multiple Pathogenic Features in Alzheimer’s Disease