Transforming liquid nicotine into a stable solid through crystallization with orotic acid-Reference-Cited by-同舟云学术

Transforming liquid nicotine into a stable solid through crystallization with orotic acid

Published:2022 Issue:35 Volume:24 Page:6155-6164
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Angevine Devin J.¹^ORCID,Camacho Kristine Joy²,Rzayev Javid³^ORCID,Benedict Jason B.⁴^ORCID

Affiliation:

1. Department of Chemistry, University at Buffalo, 730 Natural Sciences Complex, Buffalo, 14260-3000, USA

2. Department of Chemistry, University at Buffalo, 838 Natural Sciences Complex, Buffalo, 14260-3000, USA

3. Department of Chemistry, University at Buffalo, 826 Natural Sciences Complex, Buffalo, 14260-3000, USA

4. Department of Chemistry, University at Buffalo, 771 Natural Sciences Complex, Buffalo, 14260-3000, USA

Abstract

The volatile liquid active pharmaceutical ingredient, nicotine, is stabilized in the solid-state through crystallization with orotic acid. The structure, thermal properties and bonding environment are characterized and compared with previous examples.

Funder

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CE/D2CE00764A

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5. L. A.Trissel , in Handbook on Injectable Drugs , 2007 , p. 1720

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