Precise fibrin decomposition and tumor mechanics modulation with hydroxyethyl starch-based smart nanomedicine for enhanced antitumor efficacy-Reference-Cited by-同舟云学术

Precise fibrin decomposition and tumor mechanics modulation with hydroxyethyl starch-based smart nanomedicine for enhanced antitumor efficacy

Published:2022 Issue:40 Volume:10 Page:8193-8210
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Chen Jitang¹^ORCID,Zhang Zhijie¹,Li Yining¹,Zeng Haowen¹,Li Zheng¹,Wang Chong¹,Xu Chen¹,Deng Qingyuan¹,Wang Qiang¹,Yang Xiangliang¹²³⁴⁵^ORCID,Li Zifu¹²³⁴⁶^ORCID

Affiliation:

1. National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China

2. Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China

3. Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medical, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China

4. Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China

5. GBA Research Innovation Institute for Nanotechnology, Guangdong, 510530, P. R. China

6. Wuhan Institute of Biotechnology, High Tech Road 666, East Lake high tech Zone, Wuhan, 430040, P. R. China

Abstract

DOX@CREKA/tPA–HP modulates tumor mechanical properties by decomposing intratumoral fibrin, thereby decompressing tumor blood vessels, facilitating drug delivery, and augmenting antitumor effect.

Funder

Huazhong University of Science and Technology

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2022/TB/D2TB01812H

Reference79 articles.

1. Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy