A modular RNA delivery system comprising spherical nucleic acids built on endosome-escaping polymeric nanoparticles

Author:

Garcia-Guerra Antonio1234ORCID,Ellerington Ruth24ORCID,Gaitzsch Jens56ORCID,Bath Jonathan13ORCID,Kye Mahnseok24ORCID,Varela Miguel A.24ORCID,Battaglia Giuseppe578ORCID,Wood Matthew J. A.24ORCID,Manzano Raquel29ORCID,Rinaldi Carlo24ORCID,Turberfield Andrew J.13ORCID

Affiliation:

1. Department of Physics, Clarendon Laboratory, University of Oxford, Parks Road, Oxford OX1 3PU, UK

2. Department of Paediatrics, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford, OX1 3QX, UK

3. Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford, OX1 3QU, UK

4. Institute of Developmental and Regenerative Medicine (IDRM), IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford, OX3 7TY, UK

5. Department of Chemistry, University College London, London, WC1H 0AJ, UK

6. Leibniz Institute for Polymer Research Dresden, Hohe Str. 6, 01069 Dresden, Germany

7. Institute for Bioengineering of Catalonia, Barcelona Institute of Science and Technology, Baldiri Reixac, 10-12, 08028 Barcelona, Spain

8. Catalan Institution for Research and Advanced Studies, Passeig de Lluís Companys, 23, 08010 Barcelona, Spain

9. Department of Anatomy, Embryology and Animal Genetics, University of Zaragoza, Zaragoza, 50013, Spain

Abstract

Polymeric spherical nucleic acids comprise pH-sensitive, polymer-conjugated oligonucleotides that self-assemble into nanoparticles with the ability to escape endosomes, overcoming a major obstacle in nucleic acid delivery.

Funder

Medical Research Council

FP7 People: Marie-Curie Actions

Biotechnology and Biological Sciences Research Council

Wellcome Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Spherical nucleic acids for biomedical applications;Advanced Sensor and Energy Materials;2024-12

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