Co-inhibition of the TGF-β pathway and the PD-L1 checkpoint by pH-responsive clustered nanoparticles for pancreatic cancer microenvironment regulation and anti-tumor immunotherapy-Reference-Cited by-同舟云学术

Co-inhibition of the TGF-β pathway and the PD-L1 checkpoint by pH-responsive clustered nanoparticles for pancreatic cancer microenvironment regulation and anti-tumor immunotherapy

Published:2020 Issue:18 Volume:8 Page:5121-5132
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Wang Yang¹²³⁴⁵,Gao Zhuxin¹²³⁴⁵,Du Xiaojiao¹²³⁴⁵,Chen Senbiao⁶²³⁴⁵,Zhang Wangcheng⁶²³⁴⁵,Wang Jilong⁷⁸³⁴⁵,Li Hongjun⁶²³⁴⁵,He Xinyu⁶²³⁴⁵,Cao Jie¹²³⁴⁵,Wang Jun⁷⁸³⁴⁵^ORCID

Affiliation:

1. Guangzhou First People's Hospital

2. School of Medicine

3. South China University of Technology

4. Guangzhou 510006

5. P. R. China

6. Institutes for Life Sciences

7. School of Biomedical Sciences and Engineering

8. Guangzhou International Campus

Abstract

^LYiCluster_siPD-L1 could deliver LY2157299 to PSCs and release PAMAM/siPD-L1 to penetrate into tumors and target tumor cells. On synergistic therapy of both, enhanced CD8⁺ T cell infiltration and cytotoxicity were expected.

Funder

National Basic Research Program of China

National Natural Science Foundation of China

Guangzhou Science, Technology and Innovation Commission

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/BM/D0BM00916D

Reference47 articles.