The key entity of a DCAR agonist, phosphatidylinositol mannoside Ac1PIM1: its synthesis and immunomodulatory function-Reference-Cited by-同舟云学术

The key entity of a DCAR agonist, phosphatidylinositol mannoside Ac1PIM1: its synthesis and immunomodulatory function

Published:2020 Issue:19 Volume:18 Page:3659-3663
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Arai Yohei¹²³⁴,Torigoe Shota⁵⁶⁷⁴,Matsumaru Takanori¹²³⁴,Yamasaki Sho⁵⁶⁷⁴⁸,Fujimoto Yukari¹²³⁴^ORCID

Affiliation:

1. Faculty of Science and Technology

2. Keio University. Hiyoshi 3-14-1

3. Yokohama

4. Japan

5. Department of Molecular Immunology

6. Research Institute for Microbial Diseases

7. Osaka University

8. Laboratory of Molecular Immunology

Abstract

We achieved the first synthesis of phosphatidylinositol mannoside Ac₁PIM₁, and a very potent agonist of an innate immune receptor DCAR is demonstrated.

Funder

Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Takeda Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/C9OB02724F

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