One-pot synthesis of pyrazolo[4,3-<i>d</i>]thiazole derivatives containing α-aminophosphonate as potential Mur A inhibitors against MDR pathogens with radiosterilization and molecular modeling simulation-Reference-Cited by-同舟云学术

One-pot synthesis of pyrazolo[4,3-d]thiazole derivatives containing α-aminophosphonate as potential Mur A inhibitors against MDR pathogens with radiosterilization and molecular modeling simulation

Published:2023 Issue:49 Volume:13 Page:34756-34771
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Ragab Ahmed¹^ORCID,Ibrahim Seham A.²,Aboul-Magd Dina S.³,Baren Mohamed H.²

Affiliation:

1. Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo 11884, Egypt

2. Chemistry Department, Faculty of Science, Tanta University, Tanta 31527, Egypt

3. Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Egypt

Abstract

The present study involves the synthesis of a new series of α-aminophosphonate derivatives in good yields with a simple workup via the Kabachnik–Fields reaction using lithium perchlorate (LiClO4) as a catalyst to facilitate the reaction.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA07040A

Reference82 articles.

1. Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm activities with molecular modelling study

2. Synthesis and biological activity of novel small peptides with aminophosphonates moiety as NOP receptor ligands

3. Green Synthesis Using PEG‐400 Catalyst, Antimicrobial Activities, Cytotoxicity and In Silico Molecular Docking of New Carbazole Based on α‐Aminophosphonate

4. Design, synthesis and evaluation of pyrazole bearing α-aminophosphonate derivatives as potential acetylcholinesterase inhibitors against Alzheimer’s disease

5. Polyethylene glycol (PEG-400): An efficient one-pot green synthesis and anti-viral activity of novel α-diaminophosphonates

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