Controlling ionic conductivity through transprotein electropores in human aquaporin 4: a non-equilibrium molecular-dynamics study

Author:

Bernardi Mario123,Marracino Paolo123,Liberti Micaela123,Gárate José-Antonio456,Burnham Christian J.789,Apollonio Francesca123ORCID,English Niall J.789ORCID

Affiliation:

1. Dept. of Information Engineering, Electronics & Telecommunications, La Sapienza University

2. Rome

3. Italy

4. Centro Interdisciplinario de neurociencia de Valparaiso, Universidad de Valparaiso

5. Valparaiso

6. Chile

7. School of Chemical and Bioprocess Engineering, University College Dublin

8. Dublin 4

9. Ireland

Abstract

Electroporation is a matter of intensive ongoing research interest, and a much-neglected topic in trans-membrane proteins, particularly in view of such promising potential applications in medicine and biotechnology.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Reference52 articles.

1. S. L. Neidleman , Occurrence and response to environmental stressesin nonmammalian organisms , in Phospholipids Handbook , ed. G. Cevc , Marcel Dekker, Inc. , New York , 1993 , pp. 23–38

2. E. Sackmann , Physical basis of self-organization and function of membranes: physics of vesicles , in Structure and Dynamics of Membranes: From Cells to Vesicles , ed. R. Lipowski and E. Sackmann , Elsevier , Amsterdam , 1995 , pp. 213–304

3. Membrane electroporation theories: a review

4. Electric Field-Driven Water Dipoles: Nanoscale Architecture of Electroporation

5. Molecular Dynamics Simulations of Ion Conductance in Field-Stabilized Nanoscale Lipid Electropores

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