In vitro study of the blood–brain barrier transport of bioactives from Mediterranean foods

Author:

Gallardo-Fernandez Marta1ORCID,Garcia Ana Rita23,Hornedo-Ortega Ruth1,Troncoso Ana M.1ORCID,Garcia-Parrilla M. Carmen1ORCID,Brito M. Alexandra23

Affiliation:

1. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal. Facultad de Farmacia. Universidad de Sevilla. C/Profesor García González n° 2. Sevilla 41012, Spain

2. imed—Research Institute for Medicines, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal

3. Department of Pharmaceutical Sciences and Medicines, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

Abstract

Bioactives from Mediterranean diet (MD), hydroxytyrosol (HT), tyrosol (TYRS), serotonin (SER) and protocatechuic acid (PCA) cross the blood-brain barrier (BBB) and do not impair its integrity.

Funder

Ministerio de Ciencia e Innovación

Publisher

Royal Society of Chemistry (RSC)

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