Targeted antigen delivery by an anti-class II MHC VHH elicits focused αMUC1(Tn) immunity-Reference-Cited by-同舟云学术

Targeted antigen delivery by an anti-class II MHC VHH elicits focused αMUC1(Tn) immunity

Published:2017 Issue:8 Volume:8 Page:5591-5597
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Fang Tao¹²³,Van Elssen Catharina H. M. J.¹²³,Duarte Joao N.¹²³,Guzman Jonathan S.¹²³⁴⁵,Chahal Jasdave S.¹²³,Ling Jingjing¹²³⁶⁵,Ploegh Hidde L.¹²³⁴⁵^ORCID

Affiliation:

1. Whitehead Institute for Biomedical Research

2. Cambridge

3. USA

4. Department of Biology

5. Massachusetts Institute of Technology

6. Department of Chemistry

Abstract

“Sortagging” between a tumor-specific carbohydrate antigen and an APC-targeting VHH yields a robust cancer vaccine yet simple to make.

Funder

National Institutes of Health

Calouste Gulbenkian Foundation

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C7SC00446J

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4. Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components.

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