LC-MS/MS reveals the formation of aldehydes and iminium reactive intermediates in foretinib metabolism: phase I metabolic profiling
Author:
Affiliation:
1. Department of Pharmaceutical Chemistry
2. College of Pharmacy
3. King Saud University
4. Riyadh
5. Kingdom of Saudi Arabia
6. Analytical Chemistry Department
7. Faculty of Pharmacy
8. Cairo University
9. Cairo 11562
10. Egypt
Abstract
Using LC-MS/MS, six phase I foretinib metabolites in addition to four potential reactive metabolites, two aldehydes and two iminium ions, were detected and the bioactivation pathways were proposed.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA06341E
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