Cyanidin-3-O-glucoside inhibits Aβ40 fibrillogenesis, disintegrates preformed fibrils, and reduces amyloid cytotoxicity

Author:

Liu Fufeng12345ORCID,Zhao Fang12345,Wang Wenjuan12345,Sang Jingcheng12345,Jia Longgang12345ORCID,Li Li6784,Lu Fuping12345

Affiliation:

1. Key Laboratory of Industrial Fermentation Microbiology (Tianjin University of Science & Technology)

2. Ministry of Education

3. Tianjin

4. P. R. China

5. Tianjin Key Laboratory of Industrial Microbiology

6. College of Marine and Environmental Sciences

7. Tianjin University of Science & Technology

8. Tianjin 300457

Abstract

Cyanidin-3-O-glucoside, a common anthocyanin, is a potential functional inhibitor to ameliorate Alzheimer's disease by inhibiting Aβ fibrillogenesis, disrupting the mature Aβ fibrils, and reducing amyloid-induced cytotoxicity.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Tianjin City

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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