Carboxylesterase-activated near-infrared fluorescence probe for highly sensitive imaging of liver tumors

Author:

Jiang Renfeng1,Xia Yuqing2,Liu Qian2,Zhang Hongshuai32,Yang Xuefeng32,He Longwei1ORCID,Cheng Dan321ORCID

Affiliation:

1. Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, China

2. Hunan Provincial Clinical Research Center for Metabolic Associated Fatty Liver Disease, Clinical Research Institute, the Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, China

3. Department of Gastroenterology, the Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan Province, China

Abstract

A carboxylesterase-activated near-infrared fluorescent probe with high sensitivity and selectivity was developed to guide surgical resection of liver tumors and monitor clinical serum samples from liver cancer patients.

Funder

Natural Science Foundation of Hunan Province

Postdoctoral Research Foundation of China

Science and Technology Program of Hunan Province

Publisher

Royal Society of Chemistry (RSC)

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