Hesperidin protects against cisplatin-induced cardiotoxicity in mice by regulating the p62–Keap1

Hesperidin protects against cisplatin-induced cardiotoxicity in mice by regulating the p62–Keap1–Nrf2 pathway

Published:2022 Issue:7 Volume:13 Page:4205-4215
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Jia Yuxin¹,Guo Hui¹,Cheng Xizhen¹,Zhang Yuling¹,Si Mingdong¹,Shi Jing²,Ma Donglai¹³^ORCID

Affiliation:

1. School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, 050200, Hebei, China

2. Department of Scientific Research Management, the Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei, China

3. Hebei Technology Innovation Center of TCM Formula Preparations, Shijiazhuang, 050200, Hebei, China

Abstract

Hesperidin may be a potential strategy to inhibit oxidative stress-mediated inflammation and apoptosis by regulating the p62–Keap1–Nrf2 pathway in attenuating cardiotoxicity induced by cisplatin.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D2FO00298A

Reference57 articles.

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4. Unstable Angina Associated With Cisplatin and Carboplatin in a Patient With Advanced Melanoma

5. Cisplatin compromises myocardial contractile function and mitochondrial ultrastructure: Role of endoplasmic reticulum stress

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