Rhodium(<scp>i</scp>)-catalyzed directed trideuteromethylation of (hetero)arene C–H bonds with CD<sub>3</sub>CO<sub>2</sub>D-Reference-Cited by-同舟云学术

Rhodium(i)-catalyzed directed trideuteromethylation of (hetero)arene C–H bonds with CD₃CO₂D

Published:2022 Issue:38 Volume:20 Page:7645-7649
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhao Haoqiang¹²³^ORCID,Zeng Qi¹^ORCID,Yang Ji²,Xu Bing¹,Lei Haimin¹^ORCID,Xu Lijin²^ORCID,Walsh Patrick J.³^ORCID

Affiliation:

1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China

2. Department of Chemistry, Renmin University of China, Beijing 100872, China

3. Roy and Diana Vagelos Laboratories, Penn/Merck Laboratory for High-Throughput Experimentation, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA

Abstract

A Rh(i)-catalyzed trideuteromethylation of heteroarenes with inexpensive and readily available deuterated acetic acid (CD3CO2D) with the aid of aN-containing directing groups is developed.

Funder

China Scholarship Council

National Science Foundation

Beijing University of Chinese Medicine

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01581A

Reference46 articles.

1. On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition-Metal Complexes