Design, synthesis and antitubercular evaluation of benzothiazinones containing an oximido or amino nitrogen heterocycle moiety-Reference-Cited by-同舟云学术

Design, synthesis and antitubercular evaluation of benzothiazinones containing an oximido or amino nitrogen heterocycle moiety

Published:2017 Issue:3 Volume:7 Page:1480-1483
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhang Rui¹²³⁴⁵,Lv Kai¹²³⁴⁵,Wang Bin⁶⁷⁸⁹¹⁰,Li Linhu¹²³⁴⁵,Wang Bo¹²³⁴⁵,Liu Mingliang¹²³⁴⁵^ORCID,Guo Huiyuan¹²³⁴⁵,Wang Apeng¹²³⁴⁵,Lu Yu⁶⁷⁸⁹¹⁰

Affiliation:

1. Institute of Medicinal Biotechnology

2. Chinese Academy of Medical Sciences

3. Peking Union Medical College

4. Beijing 100050

5. China

6. Beijing Key Laboratory of Drug Resistance Tuberculosis Research

7. Department of Pharmacology

8. Beijing Tuberculosis and Thoracic Tumor Research Institute

9. Beijing Chest Hospital

10. Capital Medical University

Abstract

A series of 8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-ones (BTZs) bearing an oximido or amino nitrogen heterocycle moiety through modifications at the C-2 position of BTZ043 and BPTZ169 were designed and synthesized as new antitubercular agents.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C6RA25712G

Reference19 articles.

1. A Note on Derivatives of Isoniazid, Rifampicin, and Pyrazinamide Showing Activity Against ResistantMycobacterium tuberculosis

2. L. Anderson , A.Dean and D.Falzon, et al., Global tuberculosis report, World Health Organization, Geneva, 20th edn, 2015

3. Global Action Against Multidrug-Resistant Tuberculosis