Optimization of 3D autologous chondrocyte-seeded polyglycolic acid scaffolds to mimic human ear cartilage-Reference-Cited by-同舟云学术

Optimization of 3D autologous chondrocyte-seeded polyglycolic acid scaffolds to mimic human ear cartilage

Published:2023 Issue:10 Volume:11 Page:3695-3708
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Melgar-Lesmes Pedro¹²³^ORCID,Bosch Oriol⁴,Zubajlo Rebecca¹,Molins Gemma¹,Comfort Sofia¹,Luque-Saavedra Ainara⁴,López-Moya Mario¹,García-Polite Fernando¹,Parri Ferrandis Francisco José⁵,Rogers Carolyn⁶,Gelabertó Agata⁷,Martorell Jordi⁴,Edelman Elazer R.¹⁸,Balcells Mercedes¹

Affiliation:

1. Institute for Medical Engineering and Science, Massachusetts Institute of, Technology, Cambridge, MA, USA

2. Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain

3. Biochemistry and Molecular Genetics Service, Hospital Clínic Universitari, IDIBAPS, CIBERehd, Barcelona, Spain

4. Bioengineering Department, Institut Químic de Sarrià, Ramon Llull Univ, Barcelona, Spain

5. Sant Joan de Deu Hospital, Barcelona, Spain

6. Boston Children's Hospital, Boston, MA, USA

7. Asociación Española de Microtia, Madrid, Spain

8. Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

Abstract

An optimized methodology has been developed to obtain enough autologous cartilage mass to reconstruct a full-size ear using 3D-folded polyglycolic acid scaffolds and primary chondrocytes.

Funder

European Regional Development Fund

Instituto de Salud Carlos III

Ministerio de Ciencia e Innovación

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/BM/D3BM00035D

Reference50 articles.

1. Microtia: Epidemiology and genetics

2. Microtia-anotia: A global review of prevalence rates

3. Congenital microtia in a neonate due to maternal isotretinoin exposure 1 month before pregnancy: Case Report

4. Auricular reconstruction