Gold nanoparticles decorated with monosaccharides and sulfated ligands as potential modulators of the lysosomal enzyme <i>N</i>-acetylgalactosamine-6-sulfatase (GALNS)-Reference-Cited by-同舟云学术

Gold nanoparticles decorated with monosaccharides and sulfated ligands as potential modulators of the lysosomal enzyme N-acetylgalactosamine-6-sulfatase (GALNS)

Published:2023 Issue:47 Volume:21 Page:9362-9371
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Buco Francesca¹^ORCID,Matassini Camilla¹^ORCID,Vanni Costanza¹,Clemente Francesca¹^ORCID,Paoli Paolo²^ORCID,Carozzini Cosimo¹,Beni Alice¹,Cardona Francesca¹^ORCID,Goti Andrea¹^ORCID,Moya Sergio Enrique³^ORCID,Ortore Maria Grazia⁴^ORCID,Andreozzi Patrizia¹,Morrone Amelia⁵⁶,Marradi Marco¹^ORCID

Affiliation:

1. Department of Chemistry ‘Ugo Schiff’, University of Firenze, via della Lastruccia 13, Sesto Fiorentino, FI, Italy

2. Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Firenze, Italy

3. CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo Miramon 182 C, Donostia-San Sebastián 20014, Spain

4. Department of Life and Environmental Sciences, Marche Polytechnic University, Via Brecce Bianche, Ancona, I-60130, Italy

5. Laboratory of Molecular Biology of Neurometabolic Diseases, Meyer Children's Hospital, IRCCS, Viale Pieraccini 24, 50139, Firenze, Italy

6. Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, Viale Pieraccini 24, 50139 Firenze, Italy

Abstract

Modulation of N-acetylgalactosamine-6-sulfatase (GALNS) activity is a promising tool for treating metabolic disorders, neuropathic pain, and cancer. Gold nanoparticles coated with sugar and sulfated ligands were prepared and assayed for this purpose.

Funder

Central European Research Infrastructure Consortium

Elettra-Sincrotrone Trieste

Ministerio de Ciencia e Innovación

Regione Toscana

Ministero dell'Università e della Ricerca

European Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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