N6-Methyladenine hinders RNA- and DNA-directed DNA synthesis: application in human rRNA methylation analysis of clinical specimens-Reference-Cited by-同舟云学术

N6-Methyladenine hinders RNA- and DNA-directed DNA synthesis: application in human rRNA methylation analysis of clinical specimens

Published:2016 Issue:2 Volume:7 Page:1440-1446
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wang Shaoru¹²³⁴⁵,Wang Jiaqi¹²³⁴⁵,Zhang Xiaoe¹²³⁴⁵,Fu Boshi¹²³⁴⁵,Song Yanyan¹²³⁴⁵,Ma Pei⁶⁴⁷⁸,Gu Kai¹²³⁴⁵,Zhou Xin⁶⁴⁷⁸,Zhang Xiaolian⁹⁴⁷⁸,Tian Tian¹²³⁴⁵,Zhou Xiang¹²³⁴⁵

Affiliation:

1. College of Chemistry and Molecular Sciences

2. Key Laboratory of Biomedical Polymers of Ministry of Education

3. The Institute for Advanced Studies

4. Wuhan University

5. Wuhan

6. Zhongnan Hospital

7. Wuhan 430071

8. China

9. School of Medicine

Abstract

Here, we report that m⁶A significantly hinders DNA- and RNA-directed DNA synthesis, and a quantitative analysis of m⁶A in RNA or DNA context has been achieved..

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C5SC02902C

Reference48 articles.

1. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

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3. Reversible RNA adenosine methylation in biological regulation