Synthesis of 3-fluoroalkenyl-3-trifluoromethyl-2-oxindoles by the reaction of indoline-2,3-diones with difluoromethylene phosphabetaine-Reference-Cited by-同舟云学术

Synthesis of 3-fluoroalkenyl-3-trifluoromethyl-2-oxindoles by the reaction of indoline-2,3-diones with difluoromethylene phosphabetaine

Published:2016 Issue:35 Volume:52 Page:5969-5972
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Liu Yingle¹²³⁴^ORCID,Zhang Ke⁵⁶⁷⁸⁴,Huang Yangen⁵⁶⁷⁸⁴,Pan Shen⁵⁶⁷⁸⁴,Liu Xiao-Qiang¹²³⁴,Yang Yi¹²³⁴,Jiang Yan¹²³⁴,Xu Xiu-Hua⁹¹⁰¹¹¹²⁴

Affiliation:

1. School of Chemistry and Pharmaceutical Engineering

2. Sichuan University of Science & Engineering

3. Zigong

4. China

5. College of Chemistry

6. Chemical Engineering and Biotechnology

7. Donghua University

8. Shanghai 201620

9. Key Laboratory of Organofluorine Chemistry

10. Shanghai Institute of Organic Chemistry

11. Chinese Academy of Science

12. Shanghai 200032

Abstract

The reaction of indoline-2,3-diones and (triphenylphosphonio)difluoroacetate (PDFA) afforded novel 3-fluoroalkenyl-3-trifluoromethyl-2-oxindoles in moderate to excellent yields.

Funder

Education Department of Sichuan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C6CC00666C

Reference109 articles.

1. Fluorine in Pharmaceuticals: Looking Beyond Intuition

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3. The Many Roles for Fluorine in Medicinal Chemistry

4. Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

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