A copper missile-triggered power coalescence and death vortex within tumor cell mitochondria for synergistic cuproptosis/phototherapy/chemotherapy

Author:

Jiang Yicheng12,He Shuhan1,Xiang Niu1,Duan Linghui1,Lin Yuxiang1,Huang Wenyu1,Wu Zhenghong1ORCID,Qi Xiaole13ORCID

Affiliation:

1. Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing 210009, PR China

2. Center of Advanced Pharmaceuticals and Biomaterials, Ningbo Institute of Marine Medicine, Peking University, Ningbo 315832, China

3. Industrial Technology Innovation Platform, Zhejiang Center for Safety Study of Drug Substances, Hangzhou 310018, China

Abstract

The CCTH nanoparticles trigger power coalescence and death vortex within tumor cell mitochondria, producing potent anti-tumor efficacy through cuproptosis/phototherapy/chemotherapy synergistic therapy.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

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