Design of oxa-spirocyclic PHOX ligands for the asymmetric synthesis of lorcaserin via iridium-catalyzed asymmetric hydrogenation-Reference-Cited by-同舟云学术

Design of oxa-spirocyclic PHOX ligands for the asymmetric synthesis of lorcaserin via iridium-catalyzed asymmetric hydrogenation

Published:2021 Issue:2 Volume:57 Page:195-198
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Ye Xiang-Yu¹²³⁴^ORCID,Liang Zhi-Qin¹²³⁴,Jin Cong¹²³⁴,Lang Qi-Wei¹²³⁴,Chen Gen-Qiang¹²³⁴⁵^ORCID,Zhang Xumu¹²³⁴^ORCID

Affiliation:

1. Shenzhen Grubbs Institute and Department of Chemistry

2. Southern University of Science and Technology

3. Shenzhen 518000

4. People's Republic of China

5. Academy for Advanced Interdisciplinary Studies

Abstract

A series of highly rigid oxa-spiro phosphine–oxazoline ligands (O-SIPHOX) were synthesized efficiently, their iridium complexes showed high reactivity and enantioselectivity in the synthesis of key intermediate of anti-obesity drug lorcaserin.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D0CC06311H

Reference46 articles.

1. Phosphinoaryl- and phosphinoalkyloxazolines as new chiral ligands for enantioselective catalysis: Very high enantioselectivity in palladium catalyzed allylic substitutions

2. Chiral Phosphinoaryldihydrooxazoles as Ligands in Asymmetric Catalysis: Pd-Catalyzed Allylic Substitution

3. Asymmetric palladium catalysed allylic substitution using phosphorus containing oxazoline ligands

4. P. G. Andersson , Iridium Catalysis , in Topics in Organometallic Chemistry , Springer GmbH , Berlin Heidelberg , 2011

5. Q.-L. Zhou , Privileged Chiral Ligands and Catalysts , Wiley , Germany , 2011

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