Highly efficient synthesis of enantioenriched β-hydroxy α-amino acid derivatives <i>via</i> Ir-catalyzed dynamic kinetic asymmetric hydrogenation-Reference-Cited by-同舟云学术

Highly efficient synthesis of enantioenriched β-hydroxy α-amino acid derivatives via Ir-catalyzed dynamic kinetic asymmetric hydrogenation

Published:2022 Issue:22 Volume:9 Page:6247-6251
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

He Bin¹,Song Jingyuan¹,Yin Congcong¹,Chen Gen-Qiang²^ORCID,Zhang Xumu¹^ORCID

Affiliation:

1. Medi-X Pingshan and Department of Chemistry, Southern University of Science and Technology, Shenzhen 518000, People's Republic of China

2. Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen 518000, People's Republic of China

Abstract

Asymmetric hydrogenation of aryl α-dibenzylamino β-ketoesters proceeded smoothly to provide the corresponding chiral aryl β-hydroxy α-amino derivatives with excellent diastereo- and enantioselectivities (>99/1 dr, up to >99% ee).

Funder

Shenzhen Science and Technology Innovation Program

Natural Science Foundation of Shenzhen City

Special Project for Research and Development in Key areas of Guangdong Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO01121B

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