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Antifungal amphiphilic aminoglycosides

Published:2014 Issue:8 Volume:5 Page:1048-1057
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Chang C.-W. T.¹²³⁴,Takemoto J. Y.⁵²³⁴

Affiliation:

1. Department of Chemistry & Biochemistry

2. Utah State University

3. Logan

4. USA

5. Department of Biology

Abstract

A C8 alkyl chain at the O-4′′ position of kanamycin B transforms this aminoglycoside into an amphiphilic broad spectrum antifungal compound.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MD/C4MD00078A

Reference43 articles.

1. Antifungal agents: mechanisms of action

2. Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance

3. Emerging fungal threats to animal, plant and ecosystem health

4. Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: A synergistic hydrophobic effect against resistant bacteria

5. Surprising Alteration of Antibacterial Activity of 5′′-Modified Neomycin against Resistant Bacteria

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2. Synthesis of Kanamycin-Azole Hybrids and Investigation of Their Antifungal Activities;2024

3. Enantioselective Synthesis of Nabscessin C;The Journal of Organic Chemistry;2023-09-08

4. Iminated aminoglycosides in self-emulsifying drug delivery systems: Dual approach to break down the microbial defense;Journal of Colloid and Interface Science;2023-01

5. Recent developments in membrane targeting antifungal agents to mitigate antifungal resistance;RSC Medicinal Chemistry;2023

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