Glycoside hydrolase stabilization of transition state charge: new directions for inhibitor design-Reference-Cited by-同舟云学术

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Glycoside hydrolase stabilization of transition state charge: new directions for inhibitor design

Published:2020 Issue:38 Volume:11 Page:10488-10495
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Ren Weiwu¹²³⁴^ORCID,Farren-Dai Marco¹²³⁴,Sannikova Natalia¹²³⁴^ORCID,Świderek Katarzyna⁵⁶⁷⁸^ORCID,Wang Yang¹²³⁴^ORCID,Akintola Oluwafemi¹²³⁴^ORCID,Britton Robert¹²³⁴^ORCID,Moliner Vicent⁵⁶⁷⁸^ORCID,Bennet Andrew J.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Simon Fraser University

3. Burnaby

4. Canada

5. Departament de Química Física i Analítica

6. Universitat Jaume I

7. 12560 Castellón

8. Spain

Abstract

Positive charge stabilized on remote C5-allylic center with catalysis occurring via a loose S_N2 transition state.

Funder

Generalitat Valenciana

Natural Sciences and Engineering Research Council of Canada

Michael Smith Foundation for Health Research

Universitat Jaume I

Compute Canada

Ministerio de Ciencia, Innovación y Universidades

Ministerio de Economía y Competitividad

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC04401F

Reference57 articles.

1. Updating the sequence-based classification of glycosyl hydrolases

2. The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics

3. Mechanistic insights into glycosidase chemistry

4. Biochemical Analysis of Thermotoga maritima GH36 α-Galactosidase (TmGalA) Confirms the Mechanistic Commonality of Clan GH-D Glycoside Hydrolases

5. M. Sinnott , in Carbohydrate Chemistry and Biochemistry: Structure and Mechanism , RSC Publishing , Cambridge , 2nd edn, 2013

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