Visible light mediated C–H trifluoromethylation of (hetero)arenes

Author:

Xiao Fang12,Lin Jin-Hong23ORCID,Hao Fei24ORCID,Zheng Xing1,Guo Yu1ORCID,Xiao Ji-Chang2ORCID

Affiliation:

1. Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, University of South China, Hengyang, 421001, P. R. China

2. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China

3. Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai, 200444, China

4. Shandong Provincial Key Laboratory of Molecular Engineering, Qilu University of Technology – Shandong Academy of Science, Ji'nan 250353, China

Abstract

Described herein is an efficient visible light mediated trifluoromethylation of (hetero)arenes using TFSP as a CF3 source. Various aromatic (hetero)cycles could undergo this protocol to give the corresponding trifluoromethylation products.

Funder

University of South China

National Key Research and Development Program of China

National Natural Science Foundation of China

Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of China

Jinan Science and Technology Bureau

Key Research Program of Frontier Science, Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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