The casein-derived peptide YFYPEL alleviates intestinal epithelial cell dysfunction associated with NEC by regulating the PI3K/AKT signaling pathway-Reference-Cited by-同舟云学术

The casein-derived peptide YFYPEL alleviates intestinal epithelial cell dysfunction associated with NEC by regulating the PI3K/AKT signaling pathway

Published:2023 Issue:8 Volume:14 Page:3769-3778
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Chen Wenjuan¹^ORCID,Chen Yanjie¹,Qian Yun¹,Zhang Jun¹,Hu Xiaoshan¹,Yan Xiangyun¹,Jiang Chengyao¹,Yao Shuwen¹,Yu Qinlei¹,Chen Xiaohui¹,Han Shuping¹

Affiliation:

1. Department of Pediatrics, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu, China

Abstract

The effect of peptides in NEC remains poorly understood. Our study showed that YFYPEL reduced inflammation and enhanced migration by regulating the PI3K/AKT pathway. The peptide may thus develop into a novel modality in NEC treatment.

Funder

National Natural Science Foundation of China

Nanjing Medical Science and Technique Development Foundation

Natural Science Foundation of Jiangsu Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D2FO02400D

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